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Updated: Oct 4, 2025

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

Published on: May 27, 2012

Variant to function mapping at single-cell resolution through network propagation.

Fulong Yu^1,2,3, Liam D Cato^1,2,3, Chen Weng^1,2,3,4

¹Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Biorxiv : the Preprint Server for Biology

|February 4, 2022

Summary

This summary is machine-generated.

We developed SCAVENGE, a network propagation method to map genetic variants to cell types. This approach identifies disease mechanisms and cellular contexts for human genetic variation.

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Last Updated: Oct 4, 2025

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

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Published on: May 27, 2012

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Published on: October 30, 2014

Area of Science:

Genomics
Systems Biology
Computational Biology

Background:

Human disease genetic associations and single-cell atlases offer insights into disease mechanisms.
Data sparsity and noise in single-cell epigenomic data hinder the identification of relevant cell types and states.

Approach:

Developed the SCAVENGE method for mapping causal variants to cellular contexts at single-cell resolution.
Utilized network propagation to overcome data limitations in single-cell genomic data.

Key Points:

SCAVENGE identified blood trait enrichment during hematopoiesis.
Defined monocyte subsets associated with severe COVID-19 risk.
Identified lymphocyte developmental states linked to acute leukemia predisposition.

Conclusions:

SCAVENGE provides a framework for variant-to-function insights at single-cell resolution.
The method offers a general strategy for maximizing inferences from single-cell genomic data.