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Published on: May 22, 2020
Tumor microenvironment activated nanoenzyme-based agents for enhanced MRI-guided photothermal therapy in the NIR-II
Ying Chen1, Yong Liu1, Peipei Kuang1
1State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamqlfan@njupt.edu.cn.
Abstract:
We report a nanoenzyme-based photothermal agent, in which the nanoenzyme acts as a peroxidase, prodrug carrier, and MRI contrast agent. The formation of a dimer by the prodrug under the catalysis of the nanoenzyme in the tumor microenvironment causes photothermal conversion activation and MRI signal amplification simultaneously.
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