Reference intervals for coagulation tests in adults with different ABO blood types.

Area of Science:

• Hematology
• Clinical Chemistry
• Population Health

Background:

• Coagulation test results are influenced by various factors including age, race, and gestation.
• Existing reference intervals for coagulation tests do not account for variations across different ABO blood groups.
• Determining ABO blood group-specific reference ranges is crucial for accurate clinical interpretation.

Purpose of the Study:

• To investigate and establish reference ranges for key coagulation tests stratified by ABO blood group.
• To analyze variations in prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time, and fibrinogen across different blood types.
• To provide population-specific data for the Han population in South China.

Main Methods:

• Retrospective analysis of 9600 individuals aged 20-79 years.
• Data collected from the First Affiliated Hospital of Shantou University Medical College.
• Performed standard coagulation tests: PT, INR, aPTT, thrombin time, and fibrinogen.

Main Results:

• Significant differences observed in PT, INR, and aPTT values across ABO blood groups.
• Higher aPTT values were noted in individuals with blood group O compared to non-O groups.
• No significant differences in thrombin time or fibrinogen levels were found between ABO blood groups.

Conclusions:

• The study establishes crucial reference data for coagulation tests based on ABO blood groups in South China.
• Implementing ABO blood type, sex, and age-specific reference intervals can optimize clinical decisions.
• This research contributes to more precise interpretation of coagulation test results in diverse patient populations.