A Virtual Collection Focused on Antifungal Drug Discovery

Discovery of VU6052959/BI'7927: A Selective mGlu3 Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype.

ACS medicinal chemistry letters·2026

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

ACS chemical neuroscience·2026

Optimization of Pyrazole-Based Activators of Kv3.1.

ACS medicinal chemistry letters·2026

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

ACS chemical neuroscience·2026

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.

Journal of medicinal chemistry·2026

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

ACS chemical neuroscience·2026

Bacterial Aminopeptidase-Activated Peptide Prodrug Enables Species-Selective Targeting of Pseudomonas aeruginosa.

ACS infectious diseases·2026

Activity of Thiourea-Linked Diamidines against Multidrug-Resistant Staphylococcus aureus.

ACS infectious diseases·2026

Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim-Sulfamethoxazole Resistance in Burkholderia thailandensis.

ACS infectious diseases·2026

Inhibitors of the Influenza Virus Polymerase Basic 2 (PB2): Recent Advances and Future Perspectives.

ACS infectious diseases·2026

Pre-Exposure to Cyclosporine A Primes Paracoccidioides brasiliensis to Evade Host Immunity.

ACS infectious diseases·2026

A Multiplex CRISPR-Cas12a-Based Hydrogel Microarray Platform for the Simultaneous Detection of Common Adenovirus Types in Clinical Samples.

ACS infectious diseases·2026

Leveraging network pharmacology in the treatment of asthma.

ADMET & DMPK·2026

Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study.

ADMET & DMPK·2026

Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors.

ADMET & DMPK·2026

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Journal of medicinal chemistry·2026

Four Novel Quassinoid Skeletons from Brucea mollis via Guided Separation and Biomimetic Synthesis.

Organic letters·2026

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus.

Current microbiology·2026

Related Experiment Videos

A Virtual Collection Focused on Antifungal Drug Discovery

Related Concept Videos

Discovery of VU6052959/BI'7927: A Selective mGlu3 Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype.

Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease.

Optimization of Pyrazole-Based Activators of Kv3.1.

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents.

Bacterial Aminopeptidase-Activated Peptide Prodrug Enables Species-Selective Targeting of Pseudomonas aeruginosa.

Activity of Thiourea-Linked Diamidines against Multidrug-Resistant Staphylococcus aureus.

Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim-Sulfamethoxazole Resistance in Burkholderia thailandensis.

Inhibitors of the Influenza Virus Polymerase Basic 2 (PB2): Recent Advances and Future Perspectives.

Pre-Exposure to Cyclosporine A Primes Paracoccidioides brasiliensis to Evade Host Immunity.

A Multiplex CRISPR-Cas12a-Based Hydrogel Microarray Platform for the Simultaneous Detection of Common Adenovirus Types in Clinical Samples.

Leveraging network pharmacology in the treatment of asthma.

Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study.

Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors.

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Four Novel Quassinoid Skeletons from Brucea mollis via Guided Separation and Biomimetic Synthesis.

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus.

Related Experiment Videos

A Virtual Collection Focused on Antifungal Drug Discovery

Related Concept Videos

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