Related Experiment Video
Updated: Oct 4, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Microscopic Theory for the Diffusion of an Active Particle in a Crowded Environment
Pierre Rizkallah1, Alessandro Sarracino2, Olivier Bénichou3
1Sorbonne Université, CNRS, Laboratoire de Physico-Chimie des Électrolytes et Nanosystèmes Interfaciaux (PHENIX), 4 Place Jussieu, 75005 Paris, France.
Abstract:
We calculate the diffusion coefficient of an active tracer in a schematic crowded environment, represented as a lattice gas of passive particles with hardcore interactions. Starting from the master equation of the problem, we put forward a closure approximation that goes beyond trivial mean field and provides the diffusion coefficient for an arbitrary density of crowders in the system. We show that our approximation is accurate for a very wide range of parameters, and that it correctly captures numerous nonequilibrium effects, which are the signature of the activity in the system. In addition to the determination of the diffusion coefficient of the tracer, our approach allows us to characterize the perturbation of the environment induced by the displacement of the active tracer. Finally, we consider the asymptotic regimes of low and high densities, in which the expression of the diffusion coefficient of the tracer becomes explicit, and which we argue to be exact.
More Related Videos
12:32Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales
Published on: November 25, 2020
12:15Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
Published on: April 9, 2019
Related Concept Videos
Diffusion
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
Passive Diffusion: Overview and Kinetics
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
Protein Diffusion in the Membrane
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
External and Internal Respiration