Kidney graft functionality 1 year after kidney transplantation

Area of Science:

• Nephrology
• Transplant Surgery
• Public Health

Background:

• Kidney transplantation is a vital treatment for end-stage renal disease.
• Understanding post-transplant outcomes and associated factors is crucial for improving patient and graft survival.
• Limited data exists on one-year outcomes for kidney transplant recipients in Mexico.

Purpose of the Study:

• To investigate the one-year evolution, associated risk factors, and outcomes of kidney transplant recipients in Mexico.
• To analyze patient survival, graft survival, delayed graft function, and acute graft dysfunction.
• To identify key factors influencing these outcomes in a Mexican cohort.

Main Methods:

• A retrospective analysis of 1118 kidney transplant patients from a Mexican cohort (2013-2017).
• Evaluation of five key outcomes: overall survival, kidney graft survival, patient survival, delayed graft function, and acute graft dysfunction.
• Statistical analysis included Kaplan-Meier for graft survival and bivariate/multivariate analyses for risk factors (p < 0.05).

Main Results:

• One-year patient survival was 95.35% and kidney graft survival was 90.25%.
• Kidney graft loss occurred in 5.09% of patients, and 4.65% died within the follow-up year.
• Identified risk factors included transplantation from a deceased donor, recipient age over 50, and use of polyclonal agents.

Conclusions:

• Transplantation from deceased donors, older recipient age (>50 years), and use of polyclonal agents are significant risk factors for adverse outcomes.
• Patient mortality within one year is associated with infections and recipient age.
• These findings highlight critical areas for intervention to improve kidney transplant success in Mexico.