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Updated: Oct 4, 2025
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Linitis plastica: current prognostic implication of a classic concept
Aingeru Sarriugarte-Lasarte1,2,3, Eva García-Alberdi4, Silvia Pérez-Fernández2
1Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario de Cruces.
Background:
Despite having been described for several centuries linitis plastica's (LP) prognostic implication remain unclear.
Objective:
To analyze the impact of LP on the survival of patients undergoing gastrectomy for gastric adenocarcinoma.
Method:
A single-center retrospective study of cases of LP diagnosed and confirmed by pathological anatomy has been carried out in a third-level center for 5 years.
Results:
They were grouped into Linitis Plastica (LP), diffuse non-LP carcinomas (DNLP) and other adenocarcinomas (ADC). 199 gastrectomies performed in the same period of time were included in the comparative analysis. With a median follow-up of 54.5 months (95% CI: 37.0-65.0), the median survival of LP was 14 months (95% CI: 9-27) significantly lower (p = 0.002) compared to DNLP 51.5 months (95% CI: 25-70) and the rest of ADC 62 months (95% CI: 43-68). The OS at 1, 3 and 5 years was statistically worse in the LP group (69, 15, 8%) compared to DNLP (82, 54, 44%) and ADC (89, 63, 54%) (p = 0.073, p <0.001, p <0.001). In the multivariate analysis, LP was identified as an independent risk factor for OS with an HR of 3.26 (p = 0.001).
Conclusions:
LP is an independent prognostic factor associated with higher mortality in gastric cancer.
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