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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

2.7K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.7K

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Updated: Oct 4, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Parathyroid carcinoma: Single centre experience.

Clara Cunha1, Sara Lomelino Pinheiro2, Sara Donato2,3

  • 1Department of Endocrinology, Hospital de Egas Moniz, Lisboa, Portugal.

Clinical Endocrinology
|February 4, 2022
PubMed
Summary
This summary is machine-generated.

Parathyroid carcinoma, a rare cancer, often causes severe hypercalcemia and organ damage. Complete surgical removal is key, as recurrence is common and treatments are limited.

Keywords:
CDC73 mutationscarcinomahypercalcemiaparathyroid neoplasmsprimary hyperparathyroidismrecurrencesurgery

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Parathyroid carcinoma is a rare endocrine malignancy, representing less than 1% of primary hyperparathyroidism cases.
  • It is characterized by significantly elevated parathyroid hormone (PTH) levels, severe hypercalcemia, and target organ damage.

Purpose of the Study:

  • To report the management and outcomes of patients with parathyroid carcinoma at a single tertiary oncologic center.
  • To review relevant literature on parathyroid carcinoma.

Main Methods:

  • Retrospective review of patients diagnosed with parathyroid carcinoma between 1991 and 2021.
  • Analysis of clinical data, including serum calcium, PTH levels, organ damage, treatment modalities, recurrence rates, and survival outcomes.

Main Results:

  • Seventeen patients (10 males) were analyzed, with a mean age of 53 years and median follow-up of 16.5 years.
  • Most patients presented with hypercalcemia (94%) and hyperparathyroidism-mediated organ damage (94%), predominantly renal and skeletal.
  • Recurrence was observed in 47.1% of cases after a median of 24 months; 5-year overall and disease-specific survival rates were 88% and 94%, respectively. CDC73 mutations were found in 38.5% of patients.

Conclusions:

  • Parathyroid carcinoma has a high recurrence rate and limited treatment options beyond initial surgical resection.
  • A high index of suspicion preoperatively is crucial for optimal patient management.
  • This study represents the largest Portuguese cohort of parathyroid carcinoma published to date.