Opioid-Induced Constipation in Real-World Practice: A Physician Survey, 1 Year Later

Area of Science:

• Gastroenterology
• Pharmacology
• Clinical Practice

Background:

• Opioid-induced constipation (OIC) is a prevalent adverse effect of opioid therapy, frequently underdiagnosed and undertreated.
• Previous surveys highlighted variability in OIC management among Italian healthcare providers and a need for improved education and standardization.

Purpose of the Study:

• To assess progress in the diagnosis and treatment of OIC among Italian healthcare providers since a previous survey.
• To evaluate current practices and identify areas for further improvement in OIC management.

Main Methods:

• An online survey was administered to 190 Italian healthcare providers who previously participated.
• The survey included 15 questions focusing on OIC diagnosis, assessment tools, and treatment strategies.
• Responses were analyzed descriptively and aggregated by physician specialty.

Main Results:

• A majority of physicians (65%) still feel inadequately educated about OIC, despite acknowledging its impact on patient quality of life and adherence.
• Regular evaluation of intestinal function for OIC increased, with a rise in the use of specific assessment scales like Rome IV criteria.
• Prescription of peripherally acting mu-opioid receptor antagonists (PAMORAs) as second-line treatment has grown, with 46% of respondents increasing their use.

Conclusions:

• The study indicates gradual progress towards standardizing OIC diagnosis and treatment, although significant educational gaps remain.
• Enhanced educational and training initiatives are necessary to promote evidence-based clinical practices for managing OIC effectively.