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Coronary thrombo-embolic events after Covid-19 vaccination- a single centre study

Refai Showkathali1, Radhapriya Yalamanchi1, Lavanya Narra1

  • 1Department of Cardiology, Apollo Main Hospital, Chennai, India.

Indian Heart Journal
|February 5, 2022
PubMed

Insights

COVID-19 vaccination may be linked to coronary thrombo-embolic complications. This study found vaccinated patients had poorer pre-PCI TIMI flow and higher thrombus burden, though mortality rates were similar.

Area of Science:

  • Cardiology
  • Vaccinology
  • Public Health

Background:

  • Thrombo-embolic complications following COVID-19 vaccination have been reported globally.
  • Understanding these events is crucial for vaccine safety monitoring.

Purpose of the Study:

  • To investigate coronary thrombo-embolic complications (CTE) after COVID-19 vaccination in India.
  • To analyze the characteristics and outcomes of vaccinated patients experiencing Acute Coronary Syndrome (ACS).

Main Methods:

  • Retrospective analysis of 89 ACS patients with coronary thrombus admitted between March-May 2021.
  • Comparison of clinical characteristics, vaccination status, and procedural outcomes between vaccinated and unvaccinated groups.
  • Assessment of pre-Percutaneous Coronary Intervention (PCI) Thrombolysis in Myocardial Infarction (TIMI) flow and thrombus grade.

Main Results:

  • 42% of ACS patients with coronary thrombus had prior COVID-19 vaccination.
  • Vaccinated patients showed significantly lower pre-PCI TIMI flow and higher thrombus grade.
  • No significant difference in in-hospital or 30-day mortality between vaccinated and unvaccinated groups.

Conclusions:

  • This study is the first to report CTE following COVID-19 vaccination in India during the initial vaccination drive.
  • While mortality was similar, increased thrombus burden in vaccinated individuals warrants further investigation.
  • Continued monitoring for rare adverse events following COVID-19 vaccination is essential.

Keywords:
Acute Coronary syndromeCOVID-19 vaccineCoronary ThrombosisThrombo-embolicThrombusVaccine

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