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Updated: Oct 4, 2025

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Published on: August 9, 2022
Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin
Kairu Wang1, Yanshuang Hao2, Chenguang Wang3
1College of Veterinary Medicine, Hebei Agricultural University, Baoding, Hebei 071000, China.
Abstract:
A novel 1:1 cocrystal between two cardiovascular drugs, aspirin (ASA) and ligustrazine (tetramethylpyrazine, TMP) has been synthesized and characterized. The structure of this drug-drug cocrystal, ASA-TMP, was determined using single crystal X-ray crystallography. The ASA-TMP cocrystal exhibits a significantly reduced sublimation tendency than TMP. Importantly, cocrystallization simultaneously improves bioavailability of both parent drugs. This suggests the possibility of developing a more effective antithrombosis drug therapy given the synergistic pharmacological effects of the two parent drugs.
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