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Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients

Sidar Ş Aydın1, Emrah Aksakal2, Faruk Aydınyılmaz2

  • 1Department of Cardiology, Doğubeyazıt State Hospital, Ağrı, Turkey.

Angiology
|February 7, 2022
PubMed

Insights

Lipid levels, including LDL-C, HDL-C, and triglycerides, are associated with COVID-19 mortality risk. Specific levels of these lipids may predict survival outcomes in hospitalized coronavirus disease 2019 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Comorbidities increase risk for severe coronavirus disease 2019 (COVID-19).
  • Understanding predictors of mortality in hospitalized COVID-19 patients is crucial.

Purpose of the Study:

  • To investigate the relationship between blood lipid levels and mortality in patients hospitalized with COVID-19.

Main Methods:

  • Retrospective study of 4118 hospitalized COVID-19 patients.
  • Analysis of lipid profiles (LDL-C, HDL-C, TG) within 24 hours of admission.
  • Multivariable Cox proportional hazards regression to assess mortality risk.

Main Results:

  • Significant associations found between LDL-C, HDL-C, and TG levels and the risk of death (P =.002, <.001, and .035, respectively).
  • Low and high LDL-C, low HDL-C, and high TG levels were negatively associated with COVID-19-related mortality.

Conclusions:

  • Blood lipid levels may serve as useful predictors of mortality in COVID-19 patients.
  • Further research into lipid metabolism and COVID-19 outcomes is warranted.

Keywords:
COVID-19SARS-CoV-2lipid levelsmortality

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