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Related Experiment Videos

Muscle triglyceride utilization during exercise: effect of training.

B F Hurley, P M Nemeth, W H Martin

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |February 1, 1986
    PubMed
    Summary

    Endurance exercise training enhances fat utilization during exercise. Trained individuals show increased breakdown of muscle triglycerides, fueling greater fatty acid use.

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    Area of Science:

    • Exercise Physiology
    • Metabolic Adaptations
    • Muscle Metabolism

    Background:

    • Endurance training lowers respiratory exchange ratio (RER) during submaximal exercise.
    • This occurs despite lower plasma free fatty acids (FFA) and glycerol, suggesting altered substrate utilization.
    • The role of intramuscular triglycerides (IMTG) in trained individuals requires further investigation.

    Purpose of the Study:

    • To investigate whether lipolysis of muscle triglycerides is elevated in endurance-trained individuals.
    • To examine substrate utilization during prolonged exercise before and after training.

    Main Methods:

    • Nine adult males underwent a 12-week endurance training program.
    • Exercise tests at 64% maximum O2 uptake were performed pre- and post-training.

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  • Measurements included RER, plasma FFA and glycerol, and muscle triglyceride content.
  • Main Results:

    • Trained state showed lower RER and plasma FFA/glycerol during exercise.
    • Proportion of energy from fat increased from 35% to 57% post-training.
    • Muscle glycogen use decreased 41%, while muscle triglyceride breakdown doubled in the trained state.

    Conclusions:

    • Endurance training increases reliance on fat oxidation during exercise.
    • Elevated lipolysis of muscle triglycerides contributes to enhanced FFA availability and utilization in trained individuals.