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Acute Promyelocytic Leukemia with t(2;3): An Unusual Additional Chromosomal Abnormality

Smeeta Gajendra1, Anil Kumar Yadav2, Manorama Bhargava3

  • 1Laboratory Oncology Unit, Dr BRAIRCH, All India Institute of Medical Sciences, New Delhi, 110029 India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|February 7, 2022
PubMed

Insights

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. Researchers identified an unusual additional chromosomal abnormality, t(2;3), in an APL patient, adding to the known t(15;17) translocation.

Area of Science:

  • Hematology
  • Genetics
  • Oncology

Background:

  • Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia.
  • APL is characterized by specific clinical, morphological, and genetic features.
  • The PML-RAR alpha fusion gene, resulting from the t(15;17) translocation, is crucial in APL pathogenesis and considered a favorable cytogenetic feature.

Purpose of the Study:

  • To report an unusual additional chromosomal abnormality in a patient diagnosed with acute promyelocytic leukemia.
  • To highlight the genetic complexity that can be present in APL beyond the characteristic t(15;17) translocation.

Main Methods:

  • Karyotyping was performed on the bone marrow sample of the APL patient.
  • Analysis of the chromosomal abnormalities present in the patient's leukemic cells.

Main Results:

  • The patient's leukemic cells exhibited the characteristic t(15;17) translocation.
  • An additional, unusual chromosomal abnormality, t(2;3), was identified in the same patient.

Conclusions:

  • The presence of an additional t(2;3) translocation in APL is rare and noteworthy.
  • This finding expands the understanding of cytogenetic variations in acute promyelocytic leukemia.
  • Further research may be needed to determine the clinical significance of additional chromosomal abnormalities in APL.
Keywords:
Acute promyelocytic leukemiaAdditional chromosomal abnormalityKaryotypet(2;3)

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