Related Experiment Video

Updated: Oct 4, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.5K

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

Suchetana Gupta1, Ditipriya Mallick2, Kumarjeet Banerjee2

  • 1School of Mathematical and Computational Sciences, Indian Association for the Cultivation of Science, India.

Computational and Structural Biotechnology Journal
|February 7, 2022
PubMed

Keywords:
ARL6IP6, ADP Ribosylation Factor Like GTPase 6 interacting protein 6ASC, Apoptosis associated speck-like protein containing a caspase recruitment domainBLAST, Basic Local Alignment Search ToolCD4+, Cluster of Differentiation 4+CD8+, Cluster of Differentiation 8+COVID-19, Coronavirus Disease 2019Caveolin-1Cryo-EM, Cryo Electron MicroscopeGraph theoryHMOX1, Heme Oxygenase 1IFN, InterferonMERS-CoV, Middle East respiratory syndrome coronavirusMMGBSA, Molecular mechanics with generalized Born and surface area solvationMolecular dynamics simulationMutationNCBI, National Centre for Biotechnology InformationNF-NLRP3, Nucleotide-binding oligomerization domain, Leucine rich repeat and Pyrin domain containingORF, Open Reading FrameORF3aPDB, Protein Data BankPISA, Protein Interfaces Surfaces and AssembliesPROVEAN, Protein Variation Effect AnalyzerRMSD, Root Mean Square DeviationSARS-CoV-2SUN2, SUN domain-containing protein 2TRIM59, Tripartite motif-containing protein 59.

More Related Videos

Overexpressing and Purifying a Toxic Nuclease from Escherichia coli08:13

Overexpressing and Purifying a Toxic Nuclease from Escherichia coli

Published on: August 29, 2025

172
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.2K

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.3K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
385
Tail-anchoring of Proteins in the ER Membrane01:45

Tail-anchoring of Proteins in the ER Membrane

Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
3.2K