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Ceftriaxone-induced Acute Cholecystitis

Fernanda Marta Gomes1, Filipa Costeira1, Carolina Leite1

  • 1Department of Radiology, Hospital de Braga, Braga, Portugal.

Journal of Medical Ultrasound
|February 7, 2022
PubMed

Insights

Ceftriaxone use in children can lead to biliary sludge and, rarely, acute cholecystitis. This case highlights the importance of recognizing this rare but serious adverse effect of ceftriaxone therapy.

Area of Science:

  • Pediatric pharmacology
  • Gastroenterology
  • Clinical case reports

Background:

  • Ceftriaxone is a widely used antibiotic in pediatric patients due to favorable bacteriological and pharmacokinetic properties.
  • Previous literature has documented associations between ceftriaxone and biliary sludge or pseudolithiasis formation.
  • Rare instances of biliary symptoms and cholecystitis during ceftriaxone treatment have been reported.

Observation:

  • This report details a specific case of acute cholecystitis.
  • The condition was observed in a pediatric patient undergoing ceftriaxone therapy.
  • The clinical presentation and diagnostic findings are described.

Findings:

  • The case demonstrates a direct link between ceftriaxone administration and the development of acute cholecystitis.
  • Diagnostic evaluations confirmed the diagnosis of acute cholecystitis.
  • Management strategies for this ceftriaxone-induced complication are discussed.

Implications:

  • Clinicians should be aware of the potential for ceftriaxone to induce acute cholecystitis in pediatric patients.
  • Early recognition and appropriate management are crucial for favorable outcomes.
  • This case contributes to the understanding of rare adverse drug reactions in pediatric antibiotic therapy.

Keywords:
Ceftriaxonecholecystitischolecystolithiasiscontraindicationsdrug-induced

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