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Zinc deficiency impairs ischemia-induced angiogenesis
Takuya Tsuruoka1, Akio Kodama1, Shukuro Yamaguchi2
1Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jvs-Vascular Science
|February 7, 2022
Summary
Zinc deficiency impairs blood flow recovery and capillary density after hindlimb ischemia in mice. Maintaining sufficient zinc levels may aid in preventing and treating chronic limb-threatening ischemia (CLTI).
Area of Science:
- Vascular biology and trace metal metabolism.
- Investigating the role of essential nutrients in physiological processes.
Background:
- Zinc is vital for numerous bodily functions, including vascular development.
- Zinc deficiency's specific impact on angiogenesis remains unclear.
- Chronic limb-threatening ischemia (CLTI) involves impaired tissue perfusion.
Purpose of the Study:
- To investigate the effects of zinc deficiency on revascularization after ischemia.
- To examine the correlation between serum zinc levels and tissue perfusion in CLTI patients.
Main Methods:
- Unilateral hindlimb ischemia was surgically induced in zinc-deficient and control mice.
- Serum zinc levels and skin perfusion pressure (SPP) were measured in 51 CLTI patients.
- Reactive oxygen species (ROS) production and the effect of NADPH oxidase inhibitors were assessed in mice.
Main Results:
- Zinc-deficient mice exhibited reduced blood flow recovery and capillary density in ischemic limbs.
- Increased ROS production was observed in zinc-deficient mice post-ischemia.
- Serum zinc levels positively correlated with SPP in CLTI patients, confirmed by multivariate analysis.
Conclusions:
- Zinc deficiency hinders ischemia-induced revascularization by increasing oxidative stress.
- Nutritional management ensuring zinc sufficiency may be beneficial for CLTI prevention and treatment.
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