Usefulness of the Geriatric Nutritional Risk Index for Assessing Outcomes in Lower Extremity Artery Disease Following...

Lower extremity artery disease (LEAD) is a common disease associated with a higher risk of amputation and death. The Geriatric Nutritional Risk Index (GNRI) is a useful marker for assessing nutritional status; however, its relationship with outcomes in patients with LEAD following endovascular therapy (EVT) remains unclear.

This study included 127 patients who underwent initial EVT between April 2010 and December 2022. Patients were divided into 2 groups based on a GNRI score of 92. The primary endpoint was all-cause mortality; the secondary endpoint was major amputation after EVT. The median follow-up period was 47.5 months (interquartile range 34.0-61.8 months). All-cause mortality and major amputation were significantly higher in the group with a GNRI score <92 (log-rank P<0.01). GNRI was independently associated with all-cause mortality after EVT (hazard ratio 0.95 per 1-unit increase in GNRI; 95% confidence interval 0.92-0.97; P<0.01). In addition, in the claudication group, all-cause mortality and major amputation were significantly higher in the group with a GNRI score <92 (log-rank P=0.01 and P=0.02, respectively).

All-cause mortality and major amputation after EVT were significantly higher in the patients with a GNRI score <92 overall, as well as in the claudication group. These findings highlight the importance of addressing nutritional status in the early stages of LEAD to improve clinical outcomes.