[Immunologic methods for assessing neurotoxic and neuro-radiation effects in acute human radiation sickness]

A study was made of a possibility to use immunological methods (the leucocyte migration inhibition test, leukergia reaction, the test of the cold fixation of the complement with cerebral antigen) for the assessment of neurotoxic and neuroradiation effects in total therapeutic irradiation of man at a dose of 10 Gy with preceding polychemotherapy. A rapid development of agranulocytosis made cellular reactions impossible. The above effects could be assessed using humoral specific immunological reactions. A possible role of anticerebral antibodies in the pathogenesis of neurological disorders was discussed.