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Updated: Oct 4, 2025

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

Human low-density lipoprotein receptor sequence analysis.

Marwah Ali Zghair¹, Fadhil Jawad Al-Tuma², Hassan Mahmoud Abu Al-Maali³

¹Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq.

JPMA. the Journal of the Pakistan Medical Association

|February 7, 2022

Summary

This summary is machine-generated.

This study introduces a local low-density lipoprotein receptor (LDLR) sequence to GenBank, revealing evolutionary relationships and geographic associations. Findings suggest sequence similarity doesn't always imply identical function.

Keywords:

Low-density lipoprotein receptor, Sequencing, BLAST.

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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

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Published on: May 19, 2019

Area of Science:

Genetics
Molecular Biology
Bioinformatics

Background:

The low-density lipoprotein receptor (LDLR) plays a crucial role in cholesterol metabolism.
Understanding the genetic diversity of LDLR is important for studying human health and evolution.
Limited data exists on local LDLR sequences in certain geographic regions.

Purpose of the Study:

To submit a novel local low-density lipoprotein receptor sequence to the GenBank database.
To analyze the evolutionary relationships of the local LDLR sequence.
To compare the local LDLR sequence with existing sequences in GenBank.

Main Methods:

DNA was extracted from blood samples of local subjects.
A specific 150bp region of the low-density lipoprotein gene was amplified using polymerase chain reaction (PCR).
Sequencing data was analyzed using basic local alignment search tool (BLAST) software to construct a phylogenetic tree.

Main Results:

The phylogenetic analysis revealed the evolutionary connections of the local LDLR sequence with human and other species.
The study identified geographic associations in the evolutionary patterns of the low-density lipoprotein receptor.
Sequence comparison indicated potential common genetic origins for similar LDLR sequences.

Conclusions:

The newly introduced local LDLR sequence provides valuable data for the GenBank database.
Evolutionary analysis highlights geographic influences on LDLR development.
Identified sequence similarities suggest shared ancestry but do not guarantee identical functional roles for the low-density lipoprotein receptor.