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Maternal platelets in missed abortion; from a clinical perspective
Alea Farhan Salman1, Sumaya Alrawi2, Bahaa ALdeen Abdulrahman Hadi3
1The National Center of Hematology, Mustansiriyah University, Iraq.
JPMA. the Journal of the Pakistan Medical Association
|February 7, 2022
Summary
Platelet indices, including mean platelet volume and platelet distribution width, can serve as an early, cost-effective screening tool for missed abortion. Platelet distribution width showed the highest sensitivity in identifying this condition.
Area of Science:
- Obstetrics and Gynecology
- Hematology
Background:
- Missed abortion is a pregnancy complication requiring timely diagnosis.
- Early and cost-effective screening methods for missed abortion are needed.
Purpose of the Study:
- To evaluate the diagnostic significance of platelet indices, specifically mean platelet volume (MPV) and platelet distribution width (PDW), in patients with missed abortion.
- To determine if these platelet parameters can serve as an earlier and cost-beneficial screening test.
Main Methods:
- A prospective case-control study involving 30 women with missed abortion and 30 healthy controls.
- Comparison of anthropometric parameters, complete blood count, platelet count, MPV, and PDW between cases and controls.
- Statistical analysis performed using Medcalc 20.
Main Results:
- No significant difference in age between the missed abortion group (27.8±6.1 years) and the control group (25.7±5.2 years).
- All evaluated platelet parameters (platelet count, MPV, PDW) were significantly elevated in women with missed abortion compared to healthy controls (P<0.05).
Conclusions:
- Platelet indices, particularly platelet distribution width, demonstrate significant potential as early diagnostic markers for missed abortion.
- Platelet distribution width exhibited the highest sensitivity in predicting missed abortion among the studied parameters.
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