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Related Experiment Video

Updated: Oct 4, 2025

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Small fiber neuropathy.

Josef Finsterer^1,2, Fulvio A Scorza²

¹Neurology & Neurophysiology Center, Vienna, Austria.

Acta Neurologica Scandinavica

|February 7, 2022

Summary

This summary is machine-generated.

Small fiber neuropathy (SFN) treatment requires a multimodal approach, addressing underlying causes, symptoms like pain, and improving function. Individualized care based on diagnosis and etiology is crucial for effective management of this peripheral nervous system disease.

Keywords:

autonomic dysfunction outcome pain small fiber neuropathy treatment

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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Published on: February 13, 2018

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

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Published on: January 3, 2011

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

Area of Science:

Neurology
Peripheral Nervous System Disorders
Pain Management

Background:

Small fiber neuropathy (SFN) affects A-delta or C-fibers, causing pain, sensory changes, or autonomic dysfunction.
Diagnosis often relies on clinical features and reduced intra-epidermal nerve fiber density, despite lacking uniform criteria.
Treatment consensus for SFN remains limited, necessitating a review of current options.

Purpose of the Study:

To summarize and discuss available treatment options for small fiber neuropathy (SFN).
To highlight the importance of diagnosis and etiology in guiding SFN treatment strategies.

Main Methods:

This narrative review synthesizes information on SFN treatment modalities.
Classifies treatments into symptomatic, pathophysiologic, and causal approaches.

Main Results:

Symptomatic treatments include pain relievers, antidepressants, anti-seizure drugs, and topical agents for pain.
Pathophysiologic therapies target specific conditions like Fabry disease, hATTR, or immune-mediated SFN.
Causal treatments address the underlying disorders responsible for secondary SFN.

Conclusions:

Effective SFN management necessitates a multimodal strategy combining causative, pathophysiologic, and symptomatic measures.
Individualized treatment plans are essential, focusing on the patient's specific presentation, diagnosis, and etiology.
The primary goals are controlling the underlying cause, alleviating pain, and optimizing patient functionality.