Related Experiment Video
Updated: Oct 4, 2025

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Efficiency of Continuous Subcutaneous Insulin Infusion for Premature Neonate: A Case Report
Aurelie Desenfants1, Marion Soleirol2, Randa Salet2
1Department of Neonatology, CHU Nimes, Univ Montpellier, Nimes, France.
Insights
Continuous subcutaneous insulin infusion (CSII) offers a safe alternative for managing neonatal hyperglycemia in extremely low birth weight infants. This method demonstrated stable glycemic control and improved parental involvement in infant care.
Area of Science:
- Neonatology
- Pediatric Endocrinology
- Metabolic Disorders
Background:
- Neonatal hyperglycemia is prevalent in extremely low birth weight (ELBW) infants.
- It is linked to adverse clinical outcomes and typically managed with continuous intravenous insulin infusion (CIVII).
Abstract:
Neonatal hyperglycaemia is common in extremely low birth weight (ELBW, <1,000 g) infants, associated with a number of adverse clinical outcomes, and usually treated with continuous intravenous insulin infusion (CIVII). We report a case of continuous subcutaneous insulin infusion (CSII) in an ELBW neonate (730 g, 25 weeks GA) requiring insulin infusion for transient idiopathic hyperglycaemia. After presenting hyperglycaemia on day 4, the patient was treated with CIVII. From day 12 to 34, CSII was used to replace central venous catheter. Insulin requirements were lower and glycaemia more stable under CSII. No side effect was noticed. CSII was also beneficial for developmental care, allowing parents to be more easily involved in their baby's care. Thus, CSII appeared to be a safe and reliable alternative for insulin administration in ELBW infants. However, indication and management requires training of the NICU team by paediatric diabetes specialists.
Related Concept Videos
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Drug Dosing: Infants and Children
One-Compartment Model: IV Infusion
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Two-Compartment Open Model: IV Infusion
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

