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Unimanual sensorimotor learning-A simultaneous EEG-fMRI aging study.

Sabrina Chettouf1,2,3, Paul Triebkorn1,2,4, Andreas Daffertshofer3

  • 1Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

Human Brain Mapping
|February 8, 2022
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Summary
This summary is machine-generated.

Aging impairs sensorimotor coordination, with older adults showing reduced electroencephalography beta-activity during motor tasks. Brain imaging reveals distinct patterns of neural activity between younger and older individuals, highlighting age-related changes in brain networks.

Keywords:
agingcoordinationintra-hemispheric inhibitionmotor learningmotor networkperceptual motor behavior

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Area of Science:

  • Neuroscience
  • Motor Control
  • Aging Research

Background:

  • Sensorimotor coordination relies on complex brain network interactions, including inter- and intra-hemispheric communication.
  • Aging may alter these neural interactions, potentially affecting motor task performance.
  • A theoretical model proposes intra-hemispheric inhibition is crucial for compensating inter-hemispheric excitation during motor tasks.

Purpose of the Study:

  • To investigate age-related changes in brain network activity during a unimanual motor learning task.
  • To examine the relationship between electroencephalography (EEG) beta-activity, functional magnetic resonance imaging (fMRI) signals, and motor performance across age groups.

Main Methods:

  • Simultaneous EEG and fMRI data acquisition from younger (20-25 years) and older (59-70 years) healthy adults.
  • Participants learned a unimanual motor task.
  • Analysis of motor-event-related EEG beta-activity and fMRI blood oxygen level dependent (BOLD) signals.

Main Results:

  • Older adults demonstrated significantly poorer motor task performance compared to younger adults.
  • Decreased EEG beta-activity during motor tasks was observed, lateralized to contralateral motor regions, and was more pronounced in younger participants.
  • Younger adults exhibited higher mean beta-power in premotor areas during task execution than older adults.
  • fMRI BOLD signals positively correlated with EEG beta-amplitude: positive in primary motor cortex and negative in premotor cortex across both groups.

Conclusions:

  • Aging is associated with reduced sensorimotor coordination and altered neural activity patterns, specifically decreased beta-activity modulation in motor and premotor cortices.
  • The findings support the model where beta-amplitude modulation relates to primary motor cortex activation and premotor cortex deactivation.
  • Enhanced modulation in the primary motor cortex may be linked to inter-hemispheric crosstalk, which appears differently affected by aging.