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Related Concept Videos

FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

Updated: Jun 23, 2026

A Novel Method of Drug Administration to Multiple Zebrafish (Danio rerio) and the Quantification of Withdrawal
10:52

A Novel Method of Drug Administration to Multiple Zebrafish (Danio rerio) and the Quantification of Withdrawal

Published on: November 12, 2014

Fishing for drugs.

Chinyere Kemet1, Emily Hill1, Hui Feng1,2

  • 1Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, United States.

Elife
|February 8, 2022
PubMed
Summary

Screening zebrafish embryos for drugs that disrupt development can reveal new treatments. These findings may lead to therapies that effectively suppress cancer metastasis.

Keywords:
Pizotifencancerdevelopmental biologyepibolygastrulationmetastasismicephenotyping screeningzebrafish

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Last Updated: Jun 23, 2026

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Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
09:50

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

Published on: April 10, 2020

Area of Science:

  • Developmental biology
  • Cancer research
  • Pharmacology

Background:

  • Metastasis, the spread of cancer, is a major cause of cancer-related mortality.
  • Identifying novel therapeutic targets to inhibit metastasis is a critical unmet need in oncology.

Purpose of the Study:

  • To investigate the utility of zebrafish embryonic development screening for identifying drugs that inhibit cancer metastasis.

Main Methods:

  • Utilized zebrafish embryos as a model system for high-throughput drug screening.
  • Assessed the effects of screened compounds on embryonic development and metastatic potential.

Main Results:

  • Identified several compounds that disrupt normal embryonic development in zebrafish.
  • Demonstrated that a subset of these compounds also effectively suppresses metastasis in preclinical models.

Conclusions:

  • Zebrafish embryonic development screening is a viable approach for discovering anti-metastatic agents.
  • This strategy holds promise for identifying novel therapeutic strategies to combat cancer spread.