Related Experiment Video
Updated: Oct 4, 2025

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples
Published on: June 30, 2023
Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic
Ezequiel G Mogro1, Daniela Bottero1, Mauricio J Lozano1
1Instituto de Biotecnología y Biología Molecular (IBBM), CONICET, CCT-La Plata, Universidad Nacional de La Plata (UNLP), Argentina.
The SARS-CoV-2 virus shows evolving codon usage, moving away from human patterns. This suggests the virus may be becoming less pathogenic over time.
Area of Science:
- Virology
- Genomics
- Bioinformatics
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes life-threatening respiratory illnesses.
- Understanding viral evolution is crucial for managing pandemics.
Purpose of the Study:
- To analyze the evolutionary changes in SARS-CoV-2 codon usage since December 2019.
- To investigate the relationship between SARS-CoV-2 codon usage and human host patterns.
Main Methods:
- Bioinformatic analysis of complete SARS-CoV-2 genomes.
- Characterization of codon usage profiles over time.
- Assessment of codon adaptation index and effective number of codons.
Main Results:
- SARS-CoV-2 codon usage is antagonistic to and diverging from human host patterns.
- A selection of deoptimized codons was observed over time.
- A decrease in codon adaptation index and effective number of codons was noted.
Conclusions:
- SARS-CoV-2 codon usage is evolving away from the human host.
- These evolutionary changes suggest a potential decrease in viral pathogenicity.
More Related Videos
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Viral Mutations
Leaky Scanning
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Genome Size and the Evolution of New Genes
Evolutionary Relationships through Genome Comparisons