Related Experiment Video
Updated: Oct 4, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
A nonstandard finite difference scheme for the SVICDR model to predict COVID-19 dynamics
Sarah Treibert1, Helmut Brunner2, Matthias Ehrhardt1
1Chair of Applied Mathematics and Numerical Analysis, School of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal 42119, Germany.
Abstract:
In the context of 2019 coronavirus disease (COVID-19), considerable attention has been paid to mathematical models for predicting country- or region-specific future pandemic developments. In this work, we developed an SVICDR model that includes a susceptible, an all-or-nothing vaccinated, an infected, an intensive care, a deceased, and a recovered compartment. It is based on the susceptible-infectious-recovered (SIR) model of Kermack and McKendrick, which is based on ordinary differential equations (ODEs). The main objective is to show the impact of parameter boundary modifications on the predicted incidence rate, taking into account recent data on Germany in the pandemic, an exponential increasing vaccination rate in the considered time window and trigonometric contact and quarantine rate functions. For the numerical solution of the ODE systems a model-specific non-standard finite difference (NSFD) scheme is designed, that preserves the positivity of solutions and yields the correct asymptotic behaviour.
Related Concept Videos
Estimating Population Standard Deviation
Residuals and Least-Squares Property
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
Statistical Methods for Analyzing Epidemiological Data
Steps in Outbreak Investigation
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Calculating Standard Deviation
The standard deviation value is small when all the data is concentrated close to the mean. Here the data exhibits low variation. The standard deviation value is larger when the data values are more spread out from the mean. Here, the data displays high...

