Haemodynamic changes with varying chest compression rates in asphyxiated piglets
Marlies Bruckner1,2, Mattias Neset2,3, Megan O'Reilly2,4
1Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 9, 2022
Summary
Higher chest compression rates (150-180/min) in neonatal piglets significantly improved cardiac output and blood pressure during resuscitation. This suggests current guidelines may need adjustment for optimal neonatal cardiopulmonary resuscitation outcomes.
Area of Science:
- Neonatal physiology
- Cardiopulmonary resuscitation research
- Hemodynamic monitoring
Background:
- Current neonatal resuscitation guidelines recommend chest compressions (CCs) at 90/min.
- The study investigated the hemodynamic effects of varying CC rates in a neonatal model.
Purpose of the Study:
- To evaluate the impact of different chest compression rates on hemodynamic parameters in asphyxiated neonatal piglets.
- To determine optimal CC rates for neonatal cardiopulmonary resuscitation.
Main Methods:
- Six asphyxiated piglets underwent CC at rates of 60, 90, 120, 150, and 180/min for 1 minute each.
- Automated CC machine with sustained inflations was utilized.
Main Results:
- Stroke volume, left ventricle pressure change (dp/dt), and carotid blood flow increased up to 150/min, plateauing at 180/min.
- Cardiac output continuously increased, reaching its highest at 180/min.
- The highest CC rates (150-180/min) yielded the greatest cardiac output and arterial blood pressure.
Conclusions:
- Chest compression rate significantly influences hemodynamic parameters during neonatal resuscitation.
- Rates of 150-180/min during CC demonstrated superior outcomes in cardiac output and arterial blood pressure.
- Findings suggest potential for revising current neonatal resuscitation guidelines.
