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Malignant lymphoma in a Sinclair miniature pig.

P A Skavlen, H F Stills, C W Caldwell

    American Journal of Veterinary Research
    |February 1, 1986
    PubMed
    Summary

    A young Sinclair miniature pig was diagnosed with malignant lymphoma, presenting with severe symptoms and abnormal blood cell counts. Lymphoma cells extensively infiltrated organs, leading to organ dysfunction and loss of normal lymph node structure.

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    Area of Science:

    • Veterinary Pathology
    • Comparative Oncology
    • Swine Medicine

    Background:

    • Malignant lymphoma is a significant neoplastic disease in animals.
    • Early diagnosis and understanding of lymphoma presentation in miniature pigs are crucial for effective management.
    • Sinclair miniature pigs serve as a valuable model for studying various diseases, including cancers.

    Observation:

    • A 3-year-old male Sinclair miniature pig exhibited acute anorexia, depression, and fever.
    • Markedly enlarged inguinal lymph nodes and a significantly elevated leukocyte count (121,489 cells/mm3) were noted.
    • Peripheral blood analysis revealed a high number of hypodiploid lymphoblasts.

    Findings:

    • Gross necropsy showed generalized lymphadenopathy, a pale liver, and multifocal renal lesions.

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  • Microscopic examination confirmed massive infiltration of abnormal lymphoid cells into multiple organs.
  • Normal lymph node morphology was completely effaced by neoplastic lymphoid cells.

    • Implications:

    • This case highlights the aggressive nature of malignant lymphoma in this pig model.
    • Findings contribute to the understanding of lymphoma pathogenesis and clinical presentation in swine.
    • Further research into diagnostic markers and therapeutic strategies for lymphoma in pigs is warranted.