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Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Related Experiment Video

Updated: Oct 4, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Developing a Microbubble-Based Contrast Agent for Synchrotron Multiple-Image Radiography.

Ngoc Ton1, Una Goncin1, Arash Panahifar1,2

  • 1Department of Medical Imaging, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Molecular Imaging and Biology
|February 9, 2022
PubMed
Summary
This summary is machine-generated.

Lipid microbubbles (6-10 µm) show promise as contrast agents for multiple-image radiography (MIR), specifically for ultra-small-angle X-ray scattering (USAXS). A minimum concentration of 5×10⁷ microbubbles/mL is required for a detectable signal in MIR imaging.

Keywords:
Contrast agentsMicrobubblesMultiple-image radiographySynchrotronUltra-small-angle X-ray scattering

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Area of Science:

  • Medical Imaging
  • Materials Science
  • Biophysics

Background:

  • Multiple-image radiography (MIR) offers advanced X-ray imaging by separating absorption, refraction, and scattering.
  • MIR enhances contrast for soft tissues and minimizes radiation dose.
  • Developing effective contrast agents is crucial for expanding MIR applications.

Purpose of the Study:

  • To evaluate ultrasound microbubbles as contrast agents for MIR.
  • To systematically assess the impact of microbubble size, shell material, and concentration on MIR signal.

Main Methods:

  • Synthesized microbubbles with phospholipid and polyvinyl-alcohol shells in various sizes.
  • Incorporated iron oxide nanoparticles into some polymer microbubbles.
  • Immobilized microbubbles in agar at different concentrations (5×10⁵ to 5×10⁷ MBs/mL).
  • Conducted MIR imaging using Gaussian amplitude, refraction, and ultra-small-angle X-ray scattering (USAXS) techniques.

Main Results:

  • No significant differences in absorption or refraction images across microbubble types.
  • USAXS revealed a significant signal increase with 6-10 µm lipid microbubbles at the highest concentration (5×10⁷ MBs/mL).
  • Lower concentrations of lipid microbubbles did not yield a detectable USAXS signal.

Conclusions:

  • Lipid microbubbles (6-10 µm) are suitable candidates for MIR contrast agents, particularly for USAXS.
  • A minimum concentration of 5×10⁷ microbubbles/mL is necessary for detectable contrast enhancement using USAXS in MIR.