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The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens
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Epicardial Adipose Tissue in Heart Failure Phenotypes - A Meta-Analysis
Eduardo Thadeu de Oliveira Correia1, Letícia Mara Dos Santos Barbetta1, Orlando Santos da Costa1
1Universidade Federal Fluminense , Niterói , RJ - Brasil.
Arquivos Brasileiros De Cardiologia
|February 9, 2022
Summary
Epicardial adipose tissue (EAT) levels did not differ in heart failure (HF) patients overall. However, EAT was reduced in HF with reduced ejection fraction (HFrEF) and increased in HF with preserved ejection fraction (HFpEF) and mid-range ejection fraction (HFmrEF).
Area of Science:
- Cardiology
- Metabolic Research
- Biomedical Science
Background:
- Epicardial adipose tissue (EAT) is associated with comorbidities prevalent in heart failure (HF).
- EAT may play a role in mediating cardiac dysfunction.
- Understanding EAT's role in different HF phenotypes is crucial for targeted therapies.
Purpose of the Study:
- To conduct a meta-analysis investigating EAT differences in all HF types and specific HF phenotypes compared to controls.
- To determine if EAT quantity varies significantly across HF classifications.
Main Methods:
- Meta-analysis of observational studies adhering to MOOSE guidelines.
- Systematic literature search of MEDLINE, Embase, and Lilacs databases up to November 2020.
- Data extraction and quality assessment performed by two independent reviewers; p-value <0.05 considered significant.
Main Results:
- Eight studies with 1,248 patients (574 controls, 415 HF with reduced ejection fraction [HFrEF], 259 HF with mid-range or preserved ejection fraction [HFmrEF/HFpEF]) were included.
- No significant difference in EAT was found between the overall HF group and controls (SMD = -0.66, p =0.14).
- HFrEF patients showed reduced EAT (SMD = -1.27, p <0.0001), while HFmrEF/HFpEF patients exhibited increased EAT (SMD = 1.24, p <0.0001) compared to controls.
Conclusions:
- Overall EAT amount is not significantly different across all heart failure types compared to controls.
- EAT is significantly reduced in HFrEF.
- EAT is significantly increased in HFmrEF and HFpEF, suggesting distinct roles in HF pathophysiology.
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