Related Experiment Video

Updated: Oct 4, 2025

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
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Characterization of the Clinical Features in HBV-Related Acute-on-Chronic Liver Failure

Hong-Xiang Yuan, Jian-Rong Su, Qiu-Yun Zhang

    Alternative Therapies in Health and Medicine
    |February 9, 2022
    PubMed

    Insights

    Prognosis in acute-on-chronic liver failure (ACLF) is linked to prothrombin activity, hepatorenal syndrome, and hepatic encephalopathy. Understanding these factors can help reduce patient mortality in ACLF cases.

    Area of Science:

    • Hepatology
    • Internal Medicine
    • Clinical Research

    Background:

    • Acute-on-chronic liver failure (ACLF) is a significant clinical challenge, particularly in China, with poorly understood mechanisms.
    • Epidemiology, clinical features, and prognostic factors of ACLF require further investigation to improve patient outcomes.

    Purpose of the Study:

    • To investigate the epidemiology, clinical characteristics, and prognostic factors associated with ACLF.
    • To identify key indicators that predict the prognosis of patients with ACLF.

    Main Methods:

    • Retrospective study of 170 ACLF patients admitted to Beijing Friendship Hospital (November 2017 - May 2019).
    • Data collected included demographics, clinical manifestations, complications, and laboratory markers (e.g., prothrombin activity, hepatorenal syndrome, hepatic encephalopathy).
    • Logistic multivariate regression analysis was used to determine the relationship between factors and prognosis.

    Main Results:

    • The highest morbidity rates for ACLF were observed in the 40-49 and 50-59 age groups.
    • Common clinical manifestations included ascites and weakness; frequent complications were hypoalbuminemia, infection, and electrolyte imbalance.
    • Prothrombin activity (PTA), hepatorenal syndrome, and hepatic encephalopathy (level IV) were independently associated with ACLF prognosis (P < .01).

    Conclusions:

    • Prothrombin activity, hepatorenal syndrome, and hepatic encephalopathy are independent prognostic factors for ACLF.
    • These findings offer valuable insights for clinical management and strategies to reduce mortality in ACLF patients.
    Abstract

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