Asymmetric Organocatalytic Syntheses of Bioactive Compounds
Estibaliz Sansinenea1, Aurelio Ortiz1
1Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Background:
The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds.
Objectives:
In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day.
Results:
An asymmetric organocatalytic reaction is a key to generate stereoselectively the main structure with the required stereochemistry.
Conclusion:
Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with substrates are also described.
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Cycloaddition Reactions: Overview
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation


