Related Experiment Video
Updated: Oct 4, 2025
06:15
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
27.5K
Treatment Patterns and Outcomes Among Elderly Glioblastoma Patients in Riyadh, Saudi Arabia
Amal Marie1,2, Ahmed Maklad1,3, Abdullah AlTwairgi4
1Department of Radiation Oncology, Comprehensive Cancer Centre, King Fahad Medical City, Riyadh, Saudi Arabia.
Oncotargets and Therapy
|February 10, 2022
Summary
For elderly glioblastoma patients, conventional radiotherapy and completing adjuvant chemotherapy significantly improve overall survival. Earlier treatment initiation and completion of chemotherapy are linked to better progression-free survival.
Area of Science:
- Neuro-oncology
- Geriatric oncology
- Radiation oncology
Background:
- Management of glioblastoma (GBM) in elderly patients presents treatment challenges.
- Treatment decisions involve balancing aggressive therapies against palliative approaches.
Purpose of the Study:
- To evaluate treatment patterns and outcomes in elderly GBM patients.
- To identify factors influencing overall survival (OS) and progression-free survival (PFS).
Main Methods:
- Retrospective analysis of 59 elderly GBM patients treated at KFMC, Riyadh.
- Assessment of radiotherapy fractionation, surgery, and chemotherapy (CTR) in relation to OS and PFS.
Main Results:
- Conventional radiotherapy and completion of adjuvant chemotherapy were significant factors for improved OS.
- Earlier initiation of adjuvant treatment and completion of chemotherapy were associated with better PFS.
- Median OS was 12 months; median PFS was 9 months.
Conclusions:
- Conventional radiotherapy and completion of adjuvant chemotherapy are recommended for better OS in elderly GBM patients.
- Timely initiation and completion of adjuvant chemotherapy are crucial for improving PFS.
Related Concept Videos
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:21Cancer Survival Analysis
474
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
474