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Updated: Oct 4, 2025
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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
3.9K
Development of Graphene-Based Materials in Bone Tissue Engineaering.
Xiaoling Pan1,2, Delin Cheng3, Changshun Ruan3
1College of Stomatology Xinjiang Medical University Urumqi Xinjiang 830011 P. R. China.
Global Challenges (Hoboken, NJ)
|February 10, 2022
Summary
Graphene-based materials for bone regeneration show promise in tissue engineering. However, inconsistent preparation methods lead to varied biological property reports, highlighting the need for standardized fabrication and testing for clinical translation.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Graphene-based materials (GBMs) are gaining attention for bone regeneration due to unique properties.
- Applications in tissue engineering are expanding.
- Understanding research trends and mechanisms is crucial.
Purpose of the Study:
- To quantitatively analyze literature on bone regeneration-related graphene-based materials (bGBMs).
- To identify research status, hotspots, and frontiers in bGBMs.
- To provide insights for future research directions.
Main Methods:
- Scientometric analysis using CiteSpace software.
- Visualization of research trends and hotspots.
- Extraction and discussion of key subjects like fabrication, cytotoxicity, biodegradability, and osteoinductivity.
Main Results:
- Identified key research areas including fabrication techniques, cytotoxicity, biodegradability, and osteoinductivity.
- Highlighted photothermal therapy as an emerging application.
- Revealed inconsistencies in reported biological properties due to varied GBM preparation.
Conclusions:
- Lack of standardized preparation, characterization, and testing for bGBMs hinders progress.
- Establishing clear standards is essential for advancing scientific understanding and clinical translation.
- Future research should focus on standardization to ensure reliable and reproducible results.
