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Related Experiment Videos

Nematocyte differentiation in hydra.

T Fujisawa, C Nishimiya, T Sugiyama

    Current Topics in Developmental Biology
    |January 1, 1986
    PubMed
    Summary
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    A newly identified factor in hydra specifically inhibits stenotele differentiation, creating a gradient that controls nematocyte development. Nematoblasts can change their differentiation fate near the S/G2 cell cycle boundary.

    Area of Science:

    • Developmental biology
    • Cell biology
    • Stem cell research

    Background:

    • Nematocyte differentiation in hydra is position-dependent along the body axis.
    • Known morphogenetic factors for head formation do not appear to control this process.

    Purpose of the Study:

    • To identify factors responsible for position-dependent nematocyte differentiation in hydra.
    • To understand the timing and plasticity of nematoblast differentiation.

    Main Methods:

    • Identification of a novel inhibitory factor.
    • Analysis of factor gradients along the body column.
    • Experimental manipulation of nematoblast differentiation via regeneration and inhibitor treatment.

    Main Results:

    Related Experiment Videos

  • A new factor specifically inhibits stenotele nematoblast differentiation.
  • This inhibitory factor forms a gradient along the hydra body column.
  • Nematoblast differentiation fate can be altered near the S/G2 cell cycle boundary.

    • Conclusions:

    • The identified factor contributes to position-dependent nematocyte differentiation.
    • Nematoblasts may not be terminally committed until the S/G2 boundary.
    • Transdifferentiation of nematoblasts is possible at a late stage in their cell cycle.