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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Laboratory Biomarkers Associated with Severity and Mortality of COVID-19

Basmah M Azad Allarakia, Hattan Gattan, Bassam M Al-Ahmadi

    Clinical Laboratory
    |February 10, 2022
    PubMed

    Insights

    Elevated lactate dehydrogenase, blood urea nitrogen, and creatinine indicate higher risk for severe COVID-19 outcomes. These biomarkers can help predict intensive care unit (ICU) admission and mortality in patients with the virus.

    Area of Science:

    • Medical research
    • Biomarker discovery
    • Infectious disease epidemiology

    Background:

    • The COVID-19 pandemic necessitates identifying biomarkers for predicting disease severity.
    • Early identification of high-risk patients is crucial for timely intervention and mortality reduction.

    Purpose of the Study:

    • To investigate laboratory results in COVID-19 patients in Saudi Arabia.
    • To identify potential biomarkers correlated with COVID-19 disease severity.

    Main Methods:

    • Retrospective analysis of clinical records for 200 COVID-19 patients.
    • Statistical investigation of laboratory tests including coagulation parameters, D-dimer, kidney, cardiac, and liver enzymes.

    Main Results:

    • Patients admitted to the ICU were older (mean 60 years) than ward patients (mean 47 years).
    • Elevated magnesium, blood urea nitrogen, creatinine, and lactate dehydrogenase were observed in ICU and deceased patients.
    • Blood urea nitrogen and creatinine levels were significantly higher in deceased patients (p < 0.05).

    Conclusions:

    • Elevated lactate dehydrogenase, blood urea nitrogen, and creatinine levels are potential biomarkers for COVID-19 severity.
    • These markers may predict the risk of ICU admission and mortality.
    • Identifying these biomarkers can aid physicians in selecting optimal therapeutic strategies.
    Abstract

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