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In Vitro Fertilization01:24

In Vitro Fertilization

481
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Related Experiment Video

Updated: Oct 4, 2025

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

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A double-blind randomized controlled trial investigating a time-lapse algorithm for selecting Day 5 blastocysts for

Aisling Ahlström1,2, Kersti Lundin2,3, Anna-Karin Lind1,4

  • 1Livio Gothenburg, Gothenburg, Sweden.

Human Reproduction (Oxford, England)
|February 10, 2022
PubMed
Summary

A time-lapse selection model for Day 5 blastocyst transfer did not improve ongoing pregnancy rates compared to morphology alone. This study suggests current algorithms do not enhance IVF success rates when selecting embryos for transfer.

Keywords:
IVFblastocystembryo selectionsingle embryo transfertime-lapse

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Last Updated: Oct 4, 2025

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Area of Science:

  • Reproductive Medicine and Embryology
  • In Vitro Fertilization (IVF)
  • Embryo Selection Technologies

Background:

  • Time-lapse monitoring of embryo development offers insights into key developmental events correlated with viability.
  • Existing evidence does not conclusively support improved pregnancy rates using time-lapse technology for embryo selection.

Purpose of the Study:

  • To investigate if a commercially available time-lapse algorithm for Day 5 blastocyst selection improves pregnancy rates compared to morphology alone.

Main Methods:

  • A prospective, multicenter randomized controlled trial involving 776 patients undergoing fresh single embryo transfer.
  • Patients were randomized to either morphology-alone selection (control) or time-lapse model selection (intervention) for Day 5 blastocysts.
  • The primary outcome was the number of ongoing pregnancies, with embryologists blinded to group allocation during morphological scoring.

Main Results:

  • The ongoing pregnancy rate was 47.4% in the time-lapse group versus 48.1% in the morphology-alone group (mean difference -0.7%, P=0.90).
  • No statistically significant difference was observed in ongoing pregnancy rates, overall pregnancy rates, or early pregnancy loss between the groups.
  • The time-lapse algorithm altered the selection of the best blastocyst in 42% of cases, but this did not translate to improved clinical outcomes.

Conclusions:

  • The use of a commercial time-lapse selection model for Day 5 blastocysts does not enhance ongoing pregnancy rates compared to traditional morphology assessment.
  • Current time-lapse selection algorithms, when applied to morphologically good quality blastocysts, do not offer a significant advantage in fresh IVF cycles.