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Updated: Oct 4, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

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Research advances on circulating long noncoding RNAs as biomarkers of cardiovascular diseases

Mingyi Cao1, Huishan Luo1, Danning Li1

  • 1Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, China.

International Journal of Cardiology
|February 10, 2022
PubMed

Insights

Circulating long non-coding RNAs (lncRNAs) show promise as novel biomarkers for cardiovascular diseases (CVD). This review explores their clinical utility and mechanisms in diagnosing and predicting various CVD conditions.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVD) present a significant global health challenge, necessitating advanced diagnostic tools.
  • Current diagnostic methods for CVD require improvement in sensitivity and specificity.
  • Long non-coding RNAs (lncRNAs) are emerging as a critical class of molecules with potential as biomarkers.

Purpose of the Study:

  • To review the clinical application value of circulating lncRNAs as biomarkers for CVD.
  • To elucidate the pathophysiological mechanisms underlying the role of lncRNAs in CVD.
  • To summarize the diagnostic and prognostic potential of specific circulating lncRNAs in various cardiovascular conditions.

Main Methods:

  • Comprehensive literature review of studies investigating circulating lncRNAs in CVD.
  • Analysis of the scope of application and expression changes of specific lncRNAs (e.g., ZFAS1, MALAT1, HOTAIR) in different CVDs.
  • Evaluation of the pathophysiological roles and clinical potential of these lncRNAs.

Main Results:

  • Circulating lncRNAs demonstrate feasibility as diagnostic, prognostic, and predictive markers across diverse CVDs.
  • Specific lncRNAs like ZFAS1, CDR1AS, and MALAT1 are associated with conditions such as myocardial infarction and atherosclerosis.
  • Understanding lncRNA mechanisms provides insights into CVD pathogenesis.

Conclusions:

  • Circulating lncRNAs represent a promising frontier for novel biomarker development in cardiovascular medicine.
  • Further research into lncRNA function and clinical validation is crucial for integrating them into CVD diagnostics.
  • lncRNAs offer potential for improved patient stratification and therapeutic strategies in CVD management.

Keywords:
BiomarkerCardiovascular diseasesLncRNA

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