Related Experiment Video
Updated: Oct 4, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
A Systematic Review of Nudge Interventions to Optimize Medication Prescribing
Usman Talat1, Kelly Ann Schmidtke2, Saval Khanal3
1Alliance Manchester Business School, The University of Manchester, Manchester, United Kingdom.
Nudge interventions successfully optimized prescriber behavior in 80% of studies. Future interventions should target specific behavioral determinants for effective medication optimization without mandates or financial incentives.
Area of Science:
- Behavioral Science
- Health Services Research
- Clinical Pharmacy
Background:
- Medication optimization benefits are clear but challenging to implement.
- Behavior change interventions, or nudges, offer a promising approach to improve prescribing decisions without forbidding options or altering financial incentives.
- Nudges aim to optimize medication-related decisions by influencing prescriber behavior.
Purpose of the Study:
- To systematically review and characterize nudge interventions for optimizing medication prescribing.
- To analyze interventions based on the behavioral determinants they target and the techniques employed.
- To assess the alignment between targeted determinants and applied techniques.
Main Methods:
- Systematic literature search across four databases (MEDLINE, Embase, PsychINFO, CINAHL).
- Data extraction using the Theoretical Domains Framework (TDF) for behavioral determinants and the Behavior Change Techniques (BCT) Taxonomy v1 and MINDSPACE for intervention techniques.
- Appraisal of interventions using recommended TDF-BCT mappings.
Main Results:
- Fifteen studies comprising 20 interventions were identified; 16 interventions (80%) were effective.
- Prompts were the most frequently used behavior change technique (n=13).
- Defaults were the most frequently used MINDSPACE influencer (n=10); only two interventions adequately mapped TDF determinants to BCTs.
Conclusions:
- Successful interventions demonstrate the potential of nudges for optimizing prescribing without coercion.
- Future intervention design should prioritize understanding and targeting specific behavioral determinants.
- A comprehensive approach linking behavioral determinants with appropriate techniques is crucial for effective medication optimization.
Related Concept Videos
Drug Therapy
Antianxiety Medications
Dosage Regimens: Designs and Approaches
Nursing Interventions II: Selecting and Classifying the Nursing Interventions
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Nursing Interventions I: Taxonomy of Nursing Interventions
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
Factors Affecting Drug Response: Overview

