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Updated: Oct 4, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-light-promoted trifluoromethylselenolation of ortho-hydroxyarylenaminones
Linghui Lu1, Xiongjie Zhao1, Wubliker Dessie1
1Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, Hunan University of Science and Engineering, Yongzhou 425100, China. chwu_chem@yeah.net.
Abstract:
Development of an efficient process that employs easy to handle and shelf-stable reagents for the synthesis of trifluoromethylselenylated heterocyclics remains a daunting challenge in organic synthesis. Herein, we report a green and practical protocol using trifluoromethyl tolueneselenosulfonate and ortho-hydroxyarylenaminones to access a wide range of chromone derivatives under photocatalyst and oxidant free conditions. This reaction proceeded smoothly under photoirradiation conditions and various functional groups were tolerant of the reaction conditions.
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