Exudative Retinal Detachment Following Chimeric Antigen Receptor T-Cell Therapy in Relapsed B-Cell Acute...

Area of Science:

• Oncology
• Immunotherapy
• Ophthalmology

Background:

• Chimeric antigen receptor (CAR) T-cell therapy shows promise for hematologic malignancies.
• Ocular adverse effects of CAR T-cell therapy are not well-documented.

Observation:

• A pediatric patient with relapsed B-cell acute lymphoblastic leukemia and ocular involvement was treated with CAR T-cell therapy.
• The patient developed exudative retinal detachment.

Findings:

• The exudative retinal detachment was likely caused by an inflammatory response to CAR T-cell therapy.

Implications:

• This case underscores the need for vigilance regarding ocular complications following CAR T-cell therapy.
• Further research is warranted to understand and manage these potential adverse events in pediatric oncology.