[Absorbable Hemostatic Material with High Water Absorption Based on Polysaccharide].

Area of Science:

• Biomaterials Science
• Hemostasis Research
• Polymer Chemistry

Background:

• Effective hemostatic agents are crucial for managing bleeding in various medical settings.
• Current materials often face limitations in absorption capacity and hemostatic efficiency.
• Developing novel, absorbable hemostatic materials with enhanced performance is an ongoing research area.

Purpose of the Study:

• To prepare and characterize a novel polysaccharide-based hemostatic material.
• To evaluate the hemostatic efficacy and absorption properties of the developed material.
• To compare its performance against commercially available hemostatic products.

Main Methods:

• Potato starch was hydrolyzed with hydrochloric acid to increase surface area.
• Starch was crosslinked into microspheres using a crosslinking agent to improve water absorption.
• Surface modification with carboxymethyl groups further enhanced water absorption.
• Hemostatic performance was assessed using an animal model, measuring hemostatic time.

Main Results:

• The developed hemostatic material exhibited a water absorption rate exceeding 800%.
• The average hemostatic time in the animal model was 138.7 seconds.
• The material demonstrated superior hemostatic performance compared to imported products.

Conclusions:

• The novel polysaccharide-based hemostatic material effectively accelerates hemostasis by concentrating blood components.
• The crosslinked and surface-modified starch microspheres offer excellent water absorption and rapid hemostatic capabilities.
• This absorbable material presents a promising alternative to existing hemostatic agents.