Related Experiment Video
Updated: Oct 3, 2025

Imaging Ca2+ Signals in Small Pulmonary Veins at Physiological Intraluminal Pressures
Published on: March 21, 2025
[Involvement of the Piezo1 and TRPV4 stretch-activated channels in pulmonary hypertension]
S Barbeau1, T Porto Ribeiro1, G Gilbert2
1Université de Bordeaux, centre de recherche cardio-thoracique de Bordeaux, U1045, 33600 Pessac, France; Inserm, centre de recherche cardio-thoracique de Bordeaux, U1045, 33600 Pessac, France.
Abstract:
Pulmonary hypertension is a pulmonary circulation pathology characterized by remodelling and hyperreactivity of the pulmonary arteries. Vasodilatation/vasoconstriction balance is modified in favour of constriction via, among other things, the proliferation of smooth muscle cells and the development of endothelial dysfunction. In addition, the pulmonary arteries undergo modification of mechanical forces, inducing modified activation of stretch-activated channels (SAC) such as Piezo1 and TRPV4. These ionic channels are sensitive to stretch and their activation can induce various cellular physiological responses, which strongly contribute to development and continuation of the pathology.
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