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Vimentin: Regulation and pathogenesis.

Denise Paulin1, Alain Lilienbaum2, Sareen Kardjian1

  • 1Sorbonne Université, Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8256, Inserm ERL U1164, Biological Adaptation and Ageing, 75005, Paris, France.

Biochimie
|February 13, 2022
PubMed
Summary
This summary is machine-generated.

Vimentin, a key intermediate filament protein, plays roles in cell structure and signaling. Extracellular vimentin has novel functions in disease, impacting viral entry and immune response.

Keywords:
CytoskeletonEpithelial to mesenchymal transitionIntermediate filamentsPost-translational modificationsSARS-CoV-2Viral infection

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Vimentin is a crucial cytoplasmic intermediate filament protein.
  • It stabilizes intracellular structure and influences cell plasticity.
  • Vimentin interacts with signaling components and kinases, regulating gene networks.

Purpose of the Study:

  • To review the regulatory elements and epigenetic control of vimentin.
  • To explore the novel functions of extracellular vimentin.
  • To discuss the role of vimentin delocalization in diseases.

Main Methods:

  • Literature review of vimentin's regulatory mechanisms.
  • Analysis of studies on vimentin secretion and cell surface presence.
  • Examination of vimentin's role in physiological and pathological conditions.

Main Results:

  • Vimentin promoter regulation involves complex elements and epigenetic modifications.
  • Extracellular vimentin acts as a marker and receptor (e.g., for von Willebrand factor).
  • Vimentin is implicated in viral entry, pathogen invasion, and immune responses.

Conclusions:

  • Vimentin's extracellular functions are critical in various conditions.
  • Aberrant vimentin localization is linked to disease pathogenesis.
  • Understanding vimentin regulation and extracellular roles is vital for therapeutic strategies.