Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells
Soon-Gook Hong1, Junchul Shin1, Maitha Aldokhayyil2
1From the Department of Kinesiology & Cardiovascular Research Center, Temple University, Philadelphia, PA.
Exercise and Sport Sciences Reviews
|February 13, 2022
Abstract:
Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.
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