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Renal insufficiency and chronic kidney disease - Promotor or consequence of pathological post-translational

Jonas Laget1, Flore Duranton2, Àngel Argilés1

  • 1RD-Néphrologie SAS, 2 rue des Mûriers, 34090, Montpellier, France; BC2M, Université de Montpellier, Montpellier, France.

Molecular Aspects of Medicine
|February 14, 2022
PubMed

Insights

Chronic kidney disease (CKD) affects millions globally, with protein post-translational modifications (PTMs) playing a key role in its development and progression. Understanding PTMs offers new avenues for treating kidney damage and related systemic issues.

Area of Science:

  • Nephrology
  • Biochemistry
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) impacts over 840 million people worldwide.
  • Systemic changes in CKD, including oxidative stress and inflammation, affect protein function.
  • Protein post-translational modifications (PTMs) are increasingly recognized in CKD pathophysiology.

Purpose of the Study:

  • To review the intricate relationship between CKD and PTMs.
  • To explore PTMs as both causes and consequences of kidney disease.
  • To highlight the potential of targeting PTMs for therapeutic interventions.

Main Methods:

  • Literature review of recent advances in PTM detection and analysis.
  • Examination of the role of both enzymatic and non-enzymatic PTMs in kidney health and disease.
  • Analysis of therapeutic strategies targeting metabolic alterations and specific PTMs.

Main Results:

  • Non-enzymatic PTMs are common in CKD, arising from systemic changes.
  • Enzymatic PTMs are crucial for normal kidney function but can contribute to damage when altered.
  • Altered PTMs can lead to damage in kidneys, brain, and the cardiovascular system.

Conclusions:

  • PTMs are deeply interconnected with CKD, influencing its progression and severity.
  • Therapeutic strategies targeting metabolic pathways and specific PTMs show promise for treating CKD and its complications.
  • Further research into PTMs could lead to novel treatments for kidney disease and associated organ damage.
Keywords:
CKDESRDPTMsProteins

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