Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.4K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.4K
The Thyroid Gland01:23

The Thyroid Gland

4.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.6K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

78
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
78

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fetal frontal lobe development in gestational diabetes mellitus: a cross-sectional neurosonographic study.

Journal of perinatal medicine·2026
Same author

Viral hepatitis in pregnancy: integrating clinical management, perinatal outcomes, and long-term health impact.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same author

Human Papillomavirus Infection Across the Immunological Spectrum: Clinical Expression, Colposcopic Challenges, and Therapeutic Implications.

Diagnostics (Basel, Switzerland)·2026
Same author

Isolated tricuspid regurgitation in structurally normal fetal hearts: a systematic review.

Translational pediatrics·2026
Same author

Tuberculosis in Pregnancy: An Updated Narrative Review.

Diagnostics (Basel, Switzerland)·2026
Same author

Enhanced recovery after surgery (ERAS®) society guidelines for gynecologic oncology: 2026 update.

Gynecologic oncology·2026

Related Experiment Video

Updated: Oct 3, 2025

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.3K

Clinical characteristics and thyroid function in complete hydatidiform mole complicated by hyperthyroidism.

Marcos Montanha Ramos1, Izildinha Maesta2, Roberto Antonio de Araújo Costa3

  • 1Postgraduation Program in Tocoginecology, Botucatu Medical School, UNESP-São Paulo State University, Botucatu, SP, Brazil.

Gynecologic Oncology
|February 14, 2022
PubMed
Summary
This summary is machine-generated.

Women with complete hydatidiform mole (CHM) presenting with enlarged uterus, large theca lutein cysts, or high hCG levels face a higher risk of hyperthyroidism. Thyroid function typically normalizes within weeks after molar evacuation, allowing for prompt discontinuation of medications.

Keywords:
Human chorionic gonadotropinHydatidiform moleHyperthyroidismThyroid functionThyrotoxicosis

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.2K

Related Experiment Videos

Last Updated: Oct 3, 2025

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.3K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.2K

Area of Science:

  • Endocrinology
  • Gynecology
  • Oncology

Background:

  • Hyperthyroidism can complicate pregnancy, with complete hydatidiform mole (CHM) being a known risk factor.
  • Understanding clinical predictors of hyperthyroidism in CHM is crucial for timely management.

Purpose of the Study:

  • To identify clinical factors associated with hyperthyroidism at the time of CHM diagnosis.
  • To evaluate thyroid function following molar evacuation.

Main Methods:

  • An observational study of 137 women with CHM in Brazil (2002-2018).
  • Clinical data and serum hCG, TSH, and fT4 levels were collected at presentation.
  • Logistic regression and ROC curves were used to identify predictors and optimal hCG cutoffs for hyperthyroidism.

Main Results:

  • 50.3% of CHM patients presented with hyperthyroidism (subclinical or overt).
  • Uterine fundal height > 16 cm or > gestational age, and theca lutein cysts >6 cm were significantly associated with hyperthyroidism.
  • An hCG cutoff of 430,559 IU/L predicted hyperthyroidism with 85.5% sensitivity and 83.8% specificity.
  • 13% of women with hyperthyroidism experienced post-evacuation conversion to hypothyroidism.
  • Thyroid-stimulating hormone (TSH) normalized within 2-3 weeks, and free thyroxine (fT4) within 2 weeks in most cases.

Conclusions:

  • Clinical factors like uterine size, theca lutein cysts, and elevated hCG levels predict hyperthyroidism risk in CHM.
  • Thyroid function typically normalizes rapidly post-evacuation, enabling swift cessation of beta-blockers or antithyroid drugs.