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Androgens and male sexual function.

Giovanni Corona1, Giulia Rastrelli2, Linda Vignozzi2

  • 1Endocrinology Unit, Medical Department, Azienda Usl, Maggiore-Bellaria Hospital, Bologna, Italy.

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|February 14, 2022
PubMed
Summary
This summary is machine-generated.

Low testosterone (T) impacts adult male sexual function. Testosterone replacement therapy (TRT) can modestly improve sexual activity and erections in men with T deficiency, especially when combined with lifestyle changes.

Keywords:
ejaculationerectile dysfunctionsexual desiretestosteronetestosterone replacement therapy

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Area of Science:

  • Endocrinology
  • Men's Health
  • Sexual Medicine

Background:

  • Sexual symptoms are key indicators of low testosterone (T) in adult men.
  • Endogenous T levels correlate positively with sexual activity in adult males.
  • This review examines preclinical and clinical evidence on T and male sexual function.

Purpose of the Study:

  • To review evidence linking endogenous T levels to adult male sexual activity.
  • To update a meta-analysis on the effects of testosterone replacement therapy (TRT) on sexual functioning in men with T deficiency.
  • To explore the role of TRT in conjunction with lifestyle interventions.

Main Methods:

  • Narrative review of preclinical and clinical observations.
  • Updated meta-analysis of studies on TRT for testosterone deficiency.
  • Analysis of effects on sexual functioning, including erectile function.

Main Results:

  • TRT can improve sexual life aspects, including erections, in symptomatic hypogonadal men.
  • The positive effects of TRT are modest and less pronounced in men with metabolic conditions.
  • Observed effects of TRT are comparable to lifestyle interventions.

Conclusions:

  • Lifestyle modifications are the primary recommendation for weight reduction and improved health behaviors.
  • TRT may enhance willingness for physical exercise and healthier behaviors by improving body composition.
  • TRT can be a supplementary treatment for symptomatic hypogonadal men, particularly those with comorbid metabolic conditions, when combined with lifestyle interventions.