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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

3.9K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

1.7K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.7K

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Updated: Oct 3, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial.

Ning Bu1,2, Leonid Churilov3,4, Mohamed Salah Khlif5

  • 1Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Frontiers in Neurology
|February 14, 2022
PubMed
Summary

Brain volume decreases within one month after stroke, particularly in older individuals and those with white matter disease. Stroke severity did not significantly impact early brain volume loss.

Keywords:
atrophybrain volume changesclinical trialedemahemorrhagic transformationischemic stroke

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Understanding early brain volume changes after stroke is crucial.
  • The evolution of total brain volume in the initial month post-stroke remains poorly understood.

Purpose of the Study:

  • To investigate the associations between patient age, specific imaging features, and brain volume changes in the first month following an acute ischemic stroke.

Main Methods:

  • Retrospective analysis of 173 acute ischemic stroke patients from the AXIS-2 trial.
  • Total brain volume change was assessed using unified segmentation in SPM12 from hyperacute MRI to 1-month follow-up.
  • Evaluated associations between age, baseline diffusion-weighted imaging (DWI) lesion size, white matter hyperintensities (WMH), enlarged perivascular spaces (EPVSs), and lacunes with brain volume change.

Main Results:

  • A median brain volume decrease of 6 ml (0.5%) was observed over the first month post-stroke.
  • Older age was significantly associated with greater brain volume loss (5 ml per 10 years).
  • Increasing deep white matter hyperintensities (WMH) correlated with greater tissue loss (5 ml), while baseline lesion size showed no significant association.

Conclusions:

  • Brain volume changes heterogeneously in the first month after stroke.
  • Age and deep white matter disease are key factors associated with early brain volume loss post-stroke.
  • No evidence suggests that more severe strokes lead to increased early tissue loss.